Abnormal striatal dopamine and cortico-thalamic dysconnectivity in schizophrenia


  • There is a topographical association between reduced striatal dopamine synthesis capacity (SDSC) and cortico-thalamic intrinsic dysconnectivity in schizophrenia (SCZ), most likely within dopamine-modulated cortico-basal ganglia-thalamic circuits.

Why this matters

  • Abnormalities in striatal dopamine transmission and in intrinsic functional connectivity (iFC) between thalamic nuclei and distinct cortical networks are among the most consistent findings in SCZ; however, a clear link between the two has not been established.

  • Elucidation of the neurochemical and functional abnormalities underlying SCZ has important implications for the development of novel antipsychotic therapies targeted at specific areas of dysfunction, with the ultimate aim of improving outcomes and quality of life for patients.

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