Antioxidant therapy after status epilepticus induction prevents comorbidities in a preclinical model

Takeaway

  • Antioxidant treatment after epileptogenesis in rats classed as vulnerable after a stressful event, reduces seizure burden and prevents cognitive deficits and a depression-like profile.

Why this matters ?

  • A proof-of-concept study showing that vulnerability to cognitive/psychologic comorbidities (such as depression) may be halted after onset of epilepsy.

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