Assessing the safety of deferoxamine mesylate after intracerebral hemorrhage: a futility analysis


  • Treating patients with the iron chelator deferoxamine mesylate (DFO) for three consecutive days after intracerebral hemorrhage (ICH) is safe, however it would be futile to further investigate the drug’s efficacy in a large phase 3 clinical trial in patients demonstrating good clinical outcome at 90 days.

Why this matters

  • Iron is released from hemoglobin degradation products after red blood cell hemolysiswhich results in secondary neuronal injury after ICH, and evidence suggests a neuroprotective role for DFO.

  • This study reveals crucial implications for designing future clinical trials for investigating DFO in patients with ICH, which will enable to specifically target iron-mediated toxicity and secondary injury to improve patient outcomes.

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