Takeaway
Plasma neurofilament light (NfL), a marker of neuroaxonal injury, increases in response to amyloid-related neuronal injury in the preclinical stages of Alzheimer’s disease (AD) and tau-mediated neurodegeneration in the symptomatic course of the disease.
Why this matters
Plasma NfL may be a beneficial biomarker of detecting early neuronal damage in neurodegenerative diseases, such as AD and monitoring treatment effects in drug trials.