Brain connectivity in Parkinson’s disease following dopamine depletion

Takeaway

  • Topological brain changes in those with Parkinson’s disease (PD) after withdrawal from dopaminergic therapies correlate with motor symptom severity and measures of cognition.

Why this matters

  • These findings support the body of evidence that network-level hyperconnectivity may be an adaptive mechanism to compensate for neurogenerative pathologies.

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