Changes to vasculature in demyelinating optic neuritis and ischemic optic neuropathy


  • Average retinal nerve fiber layer (RNFL) was thinner in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared with patients with optic neuritis (ON).

Why this matters

  • Different systemic risk factors and future implications between NAION and ON make the correct diagnosis important for patients’ health.

  • NAION and ON can both result in optic atrophy, and patients may present after acute vision loss has resolved.

  • This study lays the groundwork for future longitudinal studies assessing diagnostic markers to differentiate NAION from ON.

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