Cognitive symptoms and later onset associated with slower progressing metachromatic leukodystrophy


  • Speed of disease progression in metachromatic leukodystrophy (MLD) is more rapid in people with an earlier onset of symptoms and is slower in people whose first symptoms are cognitive versus motor or motor and cognitive.

Why this matters

    Understanding how type and age of symptom onset is predictive of disease trajectory can inform counselling and therapy.

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