Cortical proteins may provide insight into variations in individual cognitive resilience


  • Aggregating cortical peptides associated with cognitive decline into an index score may help to identify older adults with higher cognitive resilience – a slower than anticipated cognitive decline despite the presence of Alzheimer’s disease and related dementia (ADRD) pathologies.

Why this matters?

  • Instruments to identify the level of cognitive resilience in older adults are not available due to an incomplete understanding of underlying biological mechanisms.

  • The cortical resilience peptides identified here might be potential targets for therapies that help maintain brain health in older adults.

  • Identifying adults with high or low cognitive resilience will help inform the homogeneity of study populations for clinical trials as well as facilitate risk stratification for early intervention.