Current practice and preventive epilepsy treatment in tuberous sclerosis complex


  • The notion and practice of pre-seizure electroencephalography (EEG) monitoring and epilepsy prevention in tuberous sclerosis complex (TSC) is generally implemented in most surveyed centers, despite the lack of published clinical trial results.

Why this matters

  • TSC is a rare, multisystem disease resulting from inactivating mutations in TSC1 or TSC2, causing tumors to form in multiple organs, in addition to severe, drug-resistant epilepsy in 70-90% of affected children; for which there should be a standardized treatment approach.

  • Clinicians’ standardized use of EEG monitoring and epilepsy prevention highlights awareness that early monitoring and intervention is the optimal management strategy for patients with TSC, to reduce long-term disability risk and improve outcomes as far as possible.

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