Dimethylated arginine/L-arginine ratio in progression and prognosis of amyotrophic lateral sclerosis

Takeaway

  • In a postmortem study, protein arginine methyltransferase-1 (PRMT1), which facilitates arginine methylation and accounts for >90% of production of asymmetric dimethyl -arginine (ADMA), was increased in spinal motor neurons (SMNs) of patients with amyotrophic lateral sclerosis (pwALS).

  • Cerebrospinal fluid (CSF) ADMA/-arginine ratio (ARR) had a closer relationship with survival and ALS progression than functional scores at baseline exam did; ARR was a more sensitive marker of survival than forced vital capacity (%FVC), a predictor of survival.

Why this matters ?

  • ARR was identified as a highly sensitive biomarker for early stages of ALS.

  • Dysregulated ADMA and -arginine levels could be novel therapeutic targets for ALS.