Effect of cinnamaldehyde derivatives on survival and growth of glioblastoma cells


  • Combination of 2’-hydroxycinnamaldehyde (HCA) or its derivative 2’-benzoyloxycinnamaldehyde (BCA) with temozolomide (TMZ) decreased cell viability, stemness, and invasiveness in glioblastoma (GBM) tumorspheres (TS) in vitro and slowed tumor growth in vivo in a mouse xenograft model.

  • This combination could be a new therapeutic option for slowing progression of GBM.

Why this matters ?

  • GBM is the most common primary brain tumor, highly aggressive, and associated with poor prognosis; it is frequently resistant to conventional therapies, so novel treatment strategies are desperately needed.

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