Efficacy of amantadine, modafinil, and methylphenidate for fatigue in people with multiple sclerosis


  • In a randomized, crossover, double-blind study, the use of amantadine, modafinil, and methylphenidate was similar to placebo in improving fatigue for individuals with multiple sclerosis (MS) and even resulted in more adverse events.

Why this matters

    Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in people with MS; however, studies supporting their efficacy are sparse and the data are conflicting.

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