Summary Summary Short summary of a recent publication, written by scientific experts.
In a randomized, crossover, double-blind study, the use of amantadine, modafinil, and methylphenidate was similar to placebo in improving fatigue for individuals with multiple sclerosis (MS) and even resulted in more adverse events.
Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in people with MS; however, studies supporting their efficacy are sparse and the data are conflicting.
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