First-degree relatives of children with opsoclonus-myoclonus syndrome are more likely to have autoimmune disease

Takeaway

  • High rates of familial autoimmune disease seen in children with paraneoplastic and nonparaneoplastic opsoclonus-myoclonus syndrome.

Why this matters

  • Opsoclonus-myoclonus syndrome is a rare autoimmune disorder associated with neuroblastoma in pediatrics. Although elevated rates of autoimmunity in family members of children with opsoclonus-myoclonus syndrome have previously been reported, this is the first study to differentiate between paraneoplastic and nonparaneoplastic forms. The absence of significant differences in rates between the two forms suggests that the expression of opsoclonus-myoclonus syndrome may be driven more by genetic susceptibility than the specific antigenic trigger.