Gray matter development trajectories in children with multiple sclerosis


  • Children with multiple sclerosis (MS) have impaired gray matter (GM) development in several brain regions, which is only partly related to focal white matter (WM) inflammation.

Why this matters

  • Given the partial relationship between WM inflammation and GM development, therapeutic strategies should focus on neuroprotection and neurorepair to prevent disability accrual over the long term.

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