High-dose diazepam and dyskinesia in anti-NMDA receptor encephalitis


  • High-dose enteral diazepam treatment improved dyskinesia severity in patients with anti-NMDA receptor (NMDAR) encephalitis, with no significant side-effects.

Why this matters

  • Dyskinesia is a common symptom of NMDAR encephalitis (autoimmune disorder, caused by IgG antibodies against the NR1 NMDA receptor subunit) for which there is no standard treatment; however, diazepam has been used to treat other movement disorders and is generally well-tolerated, prompting researchers to assess its efficacy in this patient cohort.

  • Diazepam’s efficacy and safety in NMDAR encephalitis-linked dyskinesia constitutes a reliable starting point for further trials to both confirm these findings and assess its long- term effects in this patient cohort.

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