How do intracranial and extracranial arterial stenosis affect stroke risk in SCD patients?

New study findings have highlighted a strong link between intracranial arterial stenosis and stroke in younger patients with sickle cell disease (SCD).

Researchers at the Vanderbilt University Medical Center in Nashville, Tennessee, USA, prospectively assessed the prevalence and contribution of intracranial and extracranial arterial stenosis to stroke risk in children and young adults (aged 6-44 years) with SCD.

In the period 2014-2019 they recruited 167 participants with SCD (79 children, 88 young adults; mean age 19.4 years), who underwent a detailed assessment including neurological examination, brain MRI, and magnetic resonance angiography (MRA) of the head and neck.

A total of 20 of the 167 participants (12%) were found to have intracranial stenosis: 5 children (6.3%) and 15 young adults (17%).

Ology Medical Education is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by Ology Medical Education for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, Ology Medical Education recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of Ology Medical Education or the sponsor. Ology Medical Education assumes no liability for any material contained herein.