How does microglial activation correlate with CSF biomarkers and cognitive decline in Alzheimer disease?

Takeaway

  • Baseline microglial activation predicts cognitive decline in Alzheimer disease (AD).

Why this matters

  • It is unclear whether neuroinflammation is associated with amyloidosis and cognitive decline in AD.

  • Microglia are involved in neuroinflammatory responses in AD pathologies of amyloid and tau. [11C]PK11195, a PET radiotracer, binds to a microglial protein 18-kDa translocator protein, to assess the microglial activation in AD.