KLOTHO heterozygosity and APOE4-related amyloid burden in preclinical Alzheimer’s disease

Takeaway

  • Heterozygosity of the KL-VS allele of the longevity gene KLOTHO potentially alters APOE4-associated β-amyloid (Aβ) aggregation.

Why this matters

  • This could confer protection against APOE4-linked pathways to disease onset in Alzheimer’s disease.