Lidocaine for the prevention of pain caused by propofol injection


  • A dose of prophylactic intravenous (IV) lidocaine based on a patient’s lean body weight (LBW) (0.306 mg/kg LBW) alleviated pain caused by the injection of medium-chain triglyceride (MCT)/long-chain triglyceride (LCT) in 50% of patients who underwent surgery under general anesthesia (GA).

Why this matters

  • Although the incidence of injection pain is lower with the use of propofol in an emulsion of 50% MCT and 50% LCT compared with the propofol formulation in 10% soybean oil LCT, various degrees of injection pain have also been reported with this formulation.

  • It is known that prophylactic administration of IV lidocaine can alleviate injection pain caused by propofol MCT/LCT emulsion but the median effective dose (ED50) of lidocaine has not been established until this study.

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