Localization of seizure onset zone, using non-invasive ictal source imaging with high-density electroencephalography (EEG) recording, is highly concordant with resective surgery or intracranial EEG (iEEG) in patients with focal epilepsy.
Why this matters
Prior to resective intervention, the gold standard curative treatment for focal epilepsy, the epileptogenic zone must be precisely defined in order to ensure successful surgery and a better prognosis for the patient. Non-invasive pre-surgical seizure mapping is currently missing from clinical practice, but as the results of this study demonstrate, it may become a critical component of patient care in the future.
Non-invasive ictal source imaging may be particularly useful when assessing patients with complex interictal activity patterns, as they tend to be challenging cases with poor prognoses.