Phase 2 evaluation of rozanolixizumab for moderate-to-severe generalized myasthenia gravis

Takeaway

  • While rozanolixizumab did not meet the primary endpoint of significant improvement in Quantitative Myasthenia Gravis (QMG) score at day 29, results of all pre-specified efficacy measures (QMG, MG-Activities of Daily Living [MG-ADL] and MG-Composite [MGC]) indicate that rozanolixizumab may provide clinical benefit for patients with moderate-to-severe generalized myasthenia gravis (gMG).

Why this matters

    Rozanolixizumab has shown dose-dependent reductions in immunoglobulin G (IgG) concentrations in healthy volunteers; its efficacy and safety in phase 2 studies of gMG will determine whether it is a viable treatment option for further consideration.

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