Progressive supranuclear palsy subtypes converge to a common phenotype

New evidence supports the observation that, over time, different subtypes of progressive supranuclear palsy (PSP) converge to a common phenotype.

“Accurate diagnosis of PSP remains a clinical challenge, especially in early stages, when the clinical features are heterogeneous”, according to Dr Gloria Martí-Andrés of the Clínica Universidad de Navarra in Pamplona, Spain. Despite the initial variability, however, evidence suggests that many patients with different PSP subtypes eventually develop similar clinical features, including oculomotor dysfunction and postural instability.