Seizure protection after neurosteroid therapy: insight into the mechanisms for sex differences


  • Greater antiseizure potency of neurosteroids occurs in females, likely due to a greater abundance of extrasynaptic δ-subunit γ-aminobutyric acid type A (GABA-A) receptors that mediate neurosteroid-sensitive tonic currents and seizure protection.

Why this matters

  • This study highlights the role of neurosteroids in sex-related seizure susceptibility, and thus strengthens the rationale for developing individualized, sex-specific neurosteroid therapies.

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