Steroid use and naïve B cells in neuromyelitis optica spectrum disorders


  • Naïve B-cell homeostasis differs from that of transitional/mature B cells and is selectively targeted by corticosteroids in neuromyelitis optica spectrum disorder (NMOSD) patients.

Why this matters

  • B cells are strongly associated with NMOSD (autoimmune disorders, characterized by optic nerve and/or spinal cord inflammation); however, their composition and outgrowth in these disorders is unclear.

  • Identification of B cells as potentially early biomarkers for NMOSD provides a positive basis for further, longitudinal study into their role in NMOSD pathophysiology, with a future aim to develop targeted therapies to enhance patient outcomes in this and related disorders.

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