Summary Summary Short summary of a recent publication, written by scientific experts.

Steroid use and naïve B cells in neuromyelitis optica spectrum disorders

Takeaway

  • Naïve B-cell homeostasis differs from that of transitional/mature B cells and is selectively targeted by corticosteroids in neuromyelitis optica spectrum disorder (NMOSD) patients.

Why this matters

  • B cells are strongly associated with NMOSD (autoimmune disorders, characterized by optic nerve and/or spinal cord inflammation); however, their composition and outgrowth in these disorders is unclear.

    • Identification of B cells as potentially early biomarkers for NMOSD provides a positive basis for further, longitudinal study into their role in NMOSD pathophysiology, with a future aim to develop targeted therapies to enhance patient outcomes in this and related disorders.

International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.

Learn more

Neuro-Ophthalmology Neuromyelitis optica spectrum disorders Transitional B cells Anti-AQP4 IgG myelin oligodendrocyte glycoprotein-IgG-associated disorder Plasmablasts