Symptom burden in limbic-predominant age-related TDP-43 encephalopathy and Alzheimer’s disease


  • Contrary to existing evidence, a combination of Alzheimer’s disease and limbic-predominant age-related TDP-43 encephalopathy (LATE) pathologies was associated with reduced symptom burden, compared with either pathology alone.

Why this matters

    Studies have suggested that dementia caused by Alzheimer’s disease and LATE is associated with greater symptom burden than Alzheimer’s disease alone. Further studies are required to examine this association.

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